New inhibitors of rabbit muscle triose-phosphate isomerase

M Fonvielle; S Mariano; M Therisod

doi:10.1016/j.bmcl.2005.03.061

New inhibitors of rabbit muscle triose-phosphate isomerase

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2906-9. doi: 10.1016/j.bmcl.2005.03.061.

Authors

M Fonvielle¹, S Mariano, M Therisod

Affiliation

¹ LCBB, ICMMO, Bat. 420, Université Paris-Sud, Orsay, France.

PMID: 15911278
DOI: 10.1016/j.bmcl.2005.03.061

Abstract

We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime: K(i) = 4.5 microM) is among the best reversible inhibitors so far reported for this enzyme.

MeSH terms

Animals
Enzyme Inhibitors / pharmacology*
Muscle, Skeletal / drug effects*
Muscle, Skeletal / enzymology
Rabbits
Triose-Phosphate Isomerase / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Triose-Phosphate Isomerase